Squamous cancer of the lung
- Sguamous carcinoma of the lung occurs after squamous metaplasia of cylindrical bronchial epithelium ( smoking, chronic bronchitis).
- Tumor sprouts as anastomosing strands and nests.
- At the periphery, are located cells of the basal layer, atypical polygonal spinous layer cells (SpCl) – with pink cytoplasme , showing intercellular bridges and mitoses.
- Cell from granulosa layer of the squamous epithelium are sparcey presented, but in differentiated forms in the centre of nests keratin is deposited forming the so called. ‘cancer pearls.
- Tumor infiltration in lymph vessels is presented with stromal ‘reaction’: with lymphocytes and plasma cells, and around necrotic areas–segmented leukocytes.