- Pathognomonic for myocarditis in rheumatism are Aschoff granulomas .
- Their typical localization is around the blood vessels in myocardium.
- The centre of granuloma is intensive pink and structurless because of fibrinoid necrosis.
- Around the area of necrosis proliferate Т-lymphocytes, plasma cells, fibroblasts, spindle giant mononuclear cells of Anichkov ( with chromatine ,pleated like ‘caterpillar’) and multinuclear giant Aschoff cells.
- Granulomas end with perivascular scarring (cicatrices), which have spindle shape.