- Arteriolar Hyalinosis in hypertonic disease affects afferent arterioles. Because of their curving way, they fall few times in the plane of section. Their walls are thick, homogenously pink, with no visible smooth muscle nuclei, and the lumens – very narrow.
- Later on, the glomeruli also hyalinize (as pink globules) along with the efferential arterioles. Because of the lack of blood in the so called ‘miracle capillary net’ (rete mirabilis) the entire nephron is atrophic.
- Single preserved glomeruli become hypertrophic thus compensating the function of the organ.