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Massive acute necrosis of liver

Massive acute necrosis of liver

Massive acute necrosis of liver

Massive acute necrosis of liver

 

  • The normal structure of the liver is unclear, which leads to difficulties in organ diagnosis.
  • Only parts of portal spaces are preserved, at some spaces only blood vessels. Bile ducts show cholestasis.
  • The rest of parenchyma is transected by extensive ‘bridging’ necroses  (centro-central, centro-portal and porto- portal).
  • Necrotic hepatocytes are replaced by a proliferation of  Kupffer cells or inflammatory cells – lymphocytes, macrophages, neutrophil leukocytes.
  • Cellular debris are impregnated with bile.
  • Only at the periphery  are left single undamaged hepatocytes or small groups of regenerated hepatocytes.
  • A ’favorable’ (with regard to patients’ life) outcome would be to develop necrotic liver cirrhosis .

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